Antimicrobial activity of three tick defensins and four mammalian cathelicidin-derived synthetic peptides against lyme disease spirochetes and bacteria isolated from the midgut

Emiko Isogai, Hiroshi Isogai, Koichi Takahashi, Michiko Kobayashi-Sakamoto, Kazuhiko Okumura

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

In this study, chemically synthesized tick defensins and cathelicidin-derived mammalian peptides were used to investigate the activity spectrum against Borrelia garinii and symbiotic Stenotrophomonas maltophila. Synthetic tick defensins showed antimicrobial activity against Staphylococcus aureus but not B. garinii and S. maltophila. Mammalian peptides which have cationic property similar to tick defensins, showed antimicrobial activity similar to tick defensins. The antimicrobial peptides in ticks and mammalian hosts have common characteristics against microbial invasion in the innate immune system.

Original languageEnglish
Pages (from-to)221-228
Number of pages8
JournalExperimental and Applied Acarology
Volume49
Issue number3
DOIs
Publication statusPublished - 2009 Oct 1

Keywords

  • Borrelia garinii
  • Defensin
  • Symbiotic bacteria
  • Synthetic antimicrobial peptides

ASJC Scopus subject areas

  • Ecology
  • Insect Science

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