Antimicrobial activity and clinical effect of cefadroxil on respiratory and urinary tract infections

Akira Watanabe, Seiichi Aonuma, Masako Sasaki, Kotaro Oizumi, Kiyoshi Konno, Izumi Hayashi

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    In vitro antimicrobial activity of cefadroxil, a new oral cephalorporin, was examined against various strains of clinical isolates, and the activity was compared among three cephalosporins, cefadroxil, cephalexin and cefazolin. Twelve clinically isolated strains of Staphylococcus aureus were inhibited the growth by cefadroxil at almost the same concentration as cephalexin and 4 to 8 fold higher concentration than cefazolin. Minimum inhibitory concentration of cefadroxil was 1.5 to 2 fold higher against 17 strains of Escherichia colt than that of cephalexin, and 4 to 8 fold higher than that of cefazolin. Against 18 strains of Klebsiella pneumoniae, MIC of cefadroxil was 2 and 8 fold higher than that of cephalexin and cefazolin. Four strains of Enterobacter revealed to be refractory to cefadroxil and 2 other cephalosporins. Twenty-five patients of respiratory tract infection and one of urinary tract infection were treated by oral administration of cefadroxil at a daily dose of 750 to 1,500 mg. As the results, therapeutic effect was excellent in 15 cases, response was good in 8 patients including a patient of pyelo-cystitis, fair in 2 patients, and poor in 1 patient. During the treatment of cefadroxil, 2 patients exhibited an elevation of serum transaminase, s-GOT and s-GPT, and 1 of them showed further an elevation of serum lactic dehydrogenase, LDH, as well as a decrease of platelet. Abnormal values of laboratory findings were only transient, and serum level and platelet count returned to normal soon after the withdrawal of the drug.

    Original languageEnglish
    Pages (from-to)106-116
    Number of pages11
    JournalChemotherapy
    Volume28
    DOIs
    Publication statusPublished - 1980 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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