TY - JOUR
T1 - Antimicrobial activities of thiolactomycin against gram‐negative anaerobes associated with periodontal disease
AU - Hamada, Shigeyuki
AU - Fujiwara, Taku
AU - Shimauchi, Hidetoshi
AU - Ogawa, Tomohiko
AU - Nishihara, Tatsuji
AU - Koga, Toshihiko
AU - Nehashi, Toshiyuki
AU - Matsuno, Takashi
PY - 1990/12
Y1 - 1990/12
N2 - Thiolactomycin (TLM), (4R)‐(2E, 5E)‐2,4,6‐trimethyl‐3‐hydroxy‐2,5,7‐octatriene‐4‐thiolide, purified from a culture filtrate of a strain of the Nocardia species, was examined for antimicrobial activities against more than 100 strains of oral and periodontally associated bacteria. Nine other commonly used antibiotics were also included for the test. We found that TLM exhibited strong and selective antimicrobial activities against Bacteroides gingivalis and other oral black‐pigmented Bacteroides species that may be etiologically associated with adult periodontitis. TLM also inhibited the growth of Actinobacillus actinomycetemcomitans, but did not affect the growth of oral streptococcal species and Eubacterium species. Strains of Eikenella corrodens were moderately susceptible to TLM, while Actinomyces viscosus strains were only slightly susceptible to it. Other antibiotics used for comparison showed a broad spectrum of antimicrobial activities in general. In conclusion, TLM exhibited highly selective antimicrobial activities to black‐pigmented Bacteroides species and A. actinomycetemcomitans, both of which are implicated in the pathogenesis of human periodontal disease.
AB - Thiolactomycin (TLM), (4R)‐(2E, 5E)‐2,4,6‐trimethyl‐3‐hydroxy‐2,5,7‐octatriene‐4‐thiolide, purified from a culture filtrate of a strain of the Nocardia species, was examined for antimicrobial activities against more than 100 strains of oral and periodontally associated bacteria. Nine other commonly used antibiotics were also included for the test. We found that TLM exhibited strong and selective antimicrobial activities against Bacteroides gingivalis and other oral black‐pigmented Bacteroides species that may be etiologically associated with adult periodontitis. TLM also inhibited the growth of Actinobacillus actinomycetemcomitans, but did not affect the growth of oral streptococcal species and Eubacterium species. Strains of Eikenella corrodens were moderately susceptible to TLM, while Actinomyces viscosus strains were only slightly susceptible to it. Other antibiotics used for comparison showed a broad spectrum of antimicrobial activities in general. In conclusion, TLM exhibited highly selective antimicrobial activities to black‐pigmented Bacteroides species and A. actinomycetemcomitans, both of which are implicated in the pathogenesis of human periodontal disease.
KW - anaerobic bacteria
KW - antibiotics
KW - periodontal disease
KW - thiolactomycin
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U2 - 10.1111/j.1399-302X.1990.tb00438.x
DO - 10.1111/j.1399-302X.1990.tb00438.x
M3 - Article
C2 - 2098714
AN - SCOPUS:0025655882
VL - 5
SP - 340
EP - 345
JO - Molecular Oral Microbiology
JF - Molecular Oral Microbiology
SN - 2041-1006
IS - 6
ER -