Antiischemic properties of fasudil in experimental models of vasospastic angina

S. I. Satoh, I. Ikegaki, T. Asano, H. Shimokawa

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

We studied the antiischemic properties of fasudil, a Rho-kinase inhibitor, in conscious rabbits with coronary vasospasm induced by vasopressin and endothelin. Pretreatment with fasudil (0.3 and 3 mg/kg) attenuated the maximum elevation of the T-wave elicited by endothelin. Pretreatment with fasudil inhibited the T-wave elevation elicited by vasopressin. Fasudil and hydroxy fasudil, an active metabolite of fasudil, relaxed the endothelin-, U-46619-, 5-hydroxytryptamine- or histamine-induced contraction in swine coronary arterial strips. Fasudil and hydroxy fasudil significantly prevented the reduction in coronary flow by vasopressin in the Langendorff perfused rat heart. Fasudil was effective in protecting the heart against vasopressin and endothelin-induced myocardial ischemic change in conscious rabbits, and this beneficial effect can be attributed to its action of ameliorating the severe contraction of arteries. The inhibition of Rho-kinase may have implications for the development of novel therapeutic strategies for vasospastic angina in patients.

Original languageEnglish
Pages (from-to)34-40
Number of pages7
JournalJapanese Journal of Pharmacology
Volume87
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Angina
  • Coronary vasospasm
  • Fasudil
  • Hydroxy fasudil
  • Rho-kinase inhibitor

ASJC Scopus subject areas

  • Pharmacology

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