TY - JOUR
T1 - Antiinflammatory effects of topical ketoconazole for the inflammation induced on the skin of hairless Guinea-pigs by repeated applications of heat-killed spores of malassezia furfur. A comparative study with hydrocortisone 17-butyrate
AU - Yoshimura, T.
AU - Kudoh, K.
AU - Aiba, S.
AU - Tagami, H.
PY - 1995
Y1 - 1995
N2 - We found that topically applied 2% ketoconazole cream showed suppressive effects on scaly erythematous lesions produced by repeated applications of heat-killed spore suspensions of Malassezia furfur to the skin of hairless guinea-pigs. The antiinflammatory effects were comparable to, but appeared later than, those of 0.1% hydrocortisone 17-butyrate cream when evaluated after 8 days of treatment. The results obtained agree well with the reported clinical efficacy of topical ketoconazole in seborrhoeic dermatitis.
AB - We found that topically applied 2% ketoconazole cream showed suppressive effects on scaly erythematous lesions produced by repeated applications of heat-killed spore suspensions of Malassezia furfur to the skin of hairless guinea-pigs. The antiinflammatory effects were comparable to, but appeared later than, those of 0.1% hydrocortisone 17-butyrate cream when evaluated after 8 days of treatment. The results obtained agree well with the reported clinical efficacy of topical ketoconazole in seborrhoeic dermatitis.
KW - Hydrocortisone 17-butyrate
KW - Malassezia furfur
KW - Seborrhoeic dermatitis
KW - Topical ketoconazole
UR - http://www.scopus.com/inward/record.url?scp=0029022759&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029022759&partnerID=8YFLogxK
U2 - 10.3109/09546639509097163
DO - 10.3109/09546639509097163
M3 - Article
AN - SCOPUS:0029022759
VL - 6
SP - 113
EP - 116
JO - Journal of Dermatological Treatment
JF - Journal of Dermatological Treatment
SN - 0954-6634
IS - 2
ER -