Antiinflammatory effects of topical ketoconazole for the inflammation induced on the skin of hairless Guinea-pigs by repeated applications of heat-killed spores of malassezia furfur. A comparative study with hydrocortisone 17-butyrate

T. Yoshimura, K. Kudoh, Setsuya Aiba, H. Tagami

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

We found that topically applied 2% ketoconazole cream showed suppressive effects on scaly erythematous lesions produced by repeated applications of heat-killed spore suspensions of Malassezia furfur to the skin of hairless guinea-pigs. The antiinflammatory effects were comparable to, but appeared later than, those of 0.1% hydrocortisone 17-butyrate cream when evaluated after 8 days of treatment. The results obtained agree well with the reported clinical efficacy of topical ketoconazole in seborrhoeic dermatitis.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalJournal of Dermatological Treatment
Volume6
Issue number2
DOIs
Publication statusPublished - 1995 Jan 1

Keywords

  • Hydrocortisone 17-butyrate
  • Malassezia furfur
  • Seborrhoeic dermatitis
  • Topical ketoconazole

ASJC Scopus subject areas

  • Dermatology

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