Antihypertensive effects of hydrolysates of wakame (Undaria pinnatifida) and their angiotensin-I-converting enzyme inhibitory activity

Minoru Sato, Takashi Oba, Toshiyasu Yamaguchi, Toshiki Nakano, Takashi Kahara, Katsura Funayama, Akio Kobayashi, Takahisa Nakano

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

Aim: The angiotensin-I-converting enzyme (ACE) inhibitory and antihypertensive activities of wakame hydrolysates have been investigated in several studies. Methods: Wakame (Undaria pinnatifida) was hydrolyzed using 17 kinds of proteases and the inhibitory activity of the hydrolysates for ACE was measured. Of these hydrolysates 4 with potent ACE inhibitory activity were administered singly and orally to spontaneously hypertensive rats (SHR). Results: The systolic blood pressure of SHR decreased significantly after single oral administration of protease S 'Amano' and proleather FG-F hydrolysates (10 mg protein/kg body weight). In a long-term feeding experiment, 7-week-old SHR were fed standard chow supplemented with protease S 'Amano'-derived wakame hydrolysates for 10 weeks. In SHR fed the 1 and 0.1% wakame hydrolysates, elevation of systolic blood pressure was still significantly suppressed for 7 weeks. Conclusions: The hydrolysates derived from wakame by protease S 'Amano' have a powerful ACE-inhibitory activity (IC50=86μg protein/ml) and were effective in spite of their slight bitterness as 'physiologically functional food' with antihypertensive activity.

Original languageEnglish
Pages (from-to)259-267
Number of pages9
JournalAnnals of Nutrition and Metabolism
Volume46
Issue number6
DOIs
Publication statusPublished - 2002

Keywords

  • Angiotensin-I-converting enzyme
  • Antihypertension
  • Blood pressure
  • Protease S 'Amano'
  • Spontaneously hypertensive rat
  • Wakame

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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