Abstract
Aim: The angiotensin-I-converting enzyme (ACE) inhibitory and antihypertensive activities of wakame hydrolysates have been investigated in several studies. Methods: Wakame (Undaria pinnatifida) was hydrolyzed using 17 kinds of proteases and the inhibitory activity of the hydrolysates for ACE was measured. Of these hydrolysates 4 with potent ACE inhibitory activity were administered singly and orally to spontaneously hypertensive rats (SHR). Results: The systolic blood pressure of SHR decreased significantly after single oral administration of protease S 'Amano' and proleather FG-F hydrolysates (10 mg protein/kg body weight). In a long-term feeding experiment, 7-week-old SHR were fed standard chow supplemented with protease S 'Amano'-derived wakame hydrolysates for 10 weeks. In SHR fed the 1 and 0.1% wakame hydrolysates, elevation of systolic blood pressure was still significantly suppressed for 7 weeks. Conclusions: The hydrolysates derived from wakame by protease S 'Amano' have a powerful ACE-inhibitory activity (IC50=86μg protein/ml) and were effective in spite of their slight bitterness as 'physiologically functional food' with antihypertensive activity.
Original language | English |
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Pages (from-to) | 259-267 |
Number of pages | 9 |
Journal | Annals of Nutrition and Metabolism |
Volume | 46 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2002 |
Keywords
- Angiotensin-I-converting enzyme
- Antihypertension
- Blood pressure
- Protease S 'Amano'
- Spontaneously hypertensive rat
- Wakame
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics