Antigen detection in the murine models of systemic candidiasis

K. Mitsutake, S. Kohno, H. Matsuda, Y. Yoshitomi, Y. Miyazaki, Y. Higashiyama, K. Tanaka, M. Iwamoto, S. Maesaki, M. Kaku

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We compared two latex agglutination tests for serum candidal antigen in murine models of systemic infection and gastrointestinal colonization. In the intravascular-infection model, mannan detection test was positive at 2 hours after inoculation, but Cand-Tec was less sensitive than mannan detection test in this model. In the gastrointestinal colonization model followed by systemic infection in neutropenic mice, the mannan antigen test became positive after 3 weeks of colonization with increased number of Candida of the stool, and Cand-Tec became positive after 5 weeks in neutropenic mice.

Original languageEnglish
Pages (from-to)716-720
Number of pages5
JournalKansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Volume66
Issue number6
DOIs
Publication statusPublished - 1992 Jun

ASJC Scopus subject areas

  • Medicine(all)

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