Antifungal activity of histatin-5 against non-albicans Candida species

H. Nikawa, C. Jin, H. Fukushima, S. Makihira, T. Hamada

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Fungicidal effects of histatin-5 against 26 oral isolates belonging to 5 non-albicans Candida species were examined. Fifty μM of histatin-5 killed more than 95% of Candida tropicalis and Candida guilliermondii isolates and more than 90% of Candida parapsilosis and Candida krusei. However, Candida glabrata was less sensitive to the peptide (mean 62.9%). Our results, taken together, demonstrated that histatin-5 possessed the fungicidal activity against Candida species other than C. glabrata.

Original languageEnglish
Pages (from-to)250-252
Number of pages3
JournalOral Microbiology and Immunology
Volume16
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • Antifungal activity
  • Candida
  • Histatin-5
  • Saliva

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Dentistry(all)
  • Microbiology (medical)

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