TY - JOUR
T1 - Antibody elimination by apheresis in living donor liver transplant recipients
AU - Kawagishi, Naoki
AU - Ohkohchi, Nobuhiro
AU - Fujimori, Keisei
AU - Orii, Takashi
AU - Koyamada, Nozomi
AU - Kikuchi, Hiroyuki
AU - Sekiguchi, Satoshi
AU - Tsukamoto, Shigeki
AU - Sato, Toshinobu
AU - Satomi, Susumu
PY - 2001
Y1 - 2001
N2 - In the present study, we investigated retrospectively the indications and the efficacy of the elimination of preexisting antiallogeneic antibodies in liver transplant recipients. Three patients who were ABO blood type incompatible were subjected to plasmapheresis and double filtration plasmapheresis before the living donor liver transplantation (LDLTx), and the titers decreased to less than 8. After transplantation, plasmapheresis was also performed in 3 cases, and continuous hemodiafiltration in 1 case, and in 2 out of these 3 patients acute rejection was recognized. Two patients who were crossmatch positive were subjected to plasmapheresis before transplantation, and the T warm titers were reduced to less than Score 2. These 2 patients had no acute rejections after transplantation. We conclude that in liver transplant patients apheresis is effective to prevent acute rejection induced by pre-existing anti-A and/or anti-B antibodies and anti-donor specific antibodies before transplantation, but it is not effective in a patient with accelerated humoral rejection occurring after transplantation.
AB - In the present study, we investigated retrospectively the indications and the efficacy of the elimination of preexisting antiallogeneic antibodies in liver transplant recipients. Three patients who were ABO blood type incompatible were subjected to plasmapheresis and double filtration plasmapheresis before the living donor liver transplantation (LDLTx), and the titers decreased to less than 8. After transplantation, plasmapheresis was also performed in 3 cases, and continuous hemodiafiltration in 1 case, and in 2 out of these 3 patients acute rejection was recognized. Two patients who were crossmatch positive were subjected to plasmapheresis before transplantation, and the T warm titers were reduced to less than Score 2. These 2 patients had no acute rejections after transplantation. We conclude that in liver transplant patients apheresis is effective to prevent acute rejection induced by pre-existing anti-A and/or anti-B antibodies and anti-donor specific antibodies before transplantation, but it is not effective in a patient with accelerated humoral rejection occurring after transplantation.
KW - ABO incompatible
KW - Crossmatch
KW - Liver transplantation
KW - Living donor
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U2 - 10.1046/j.1526-0968.2001.00376.x
DO - 10.1046/j.1526-0968.2001.00376.x
M3 - Article
C2 - 11800079
AN - SCOPUS:0035670695
VL - 5
SP - 449
EP - 454
JO - Therapeutic Apheresis and Dialysis
JF - Therapeutic Apheresis and Dialysis
SN - 1744-9979
IS - 6
ER -