Antibody elimination by apheresis in living donor liver transplant recipients

Naoki Kawagishi, Nobuhiro Ohkohchi, Keisei Fujimori, Takashi Orii, Nozomi Koyamada, Hiroyuki Kikuchi, Satoshi Sekiguchi, Shigeki Tsukamoto, Toshinobu Sato, Susumu Satomi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In the present study, we investigated retrospectively the indications and the efficacy of the elimination of preexisting antiallogeneic antibodies in liver transplant recipients. Three patients who were ABO blood type incompatible were subjected to plasmapheresis and double filtration plasmapheresis before the living donor liver transplantation (LDLTx), and the titers decreased to less than 8. After transplantation, plasmapheresis was also performed in 3 cases, and continuous hemodiafiltration in 1 case, and in 2 out of these 3 patients acute rejection was recognized. Two patients who were crossmatch positive were subjected to plasmapheresis before transplantation, and the T warm titers were reduced to less than Score 2. These 2 patients had no acute rejections after transplantation. We conclude that in liver transplant patients apheresis is effective to prevent acute rejection induced by pre-existing anti-A and/or anti-B antibodies and anti-donor specific antibodies before transplantation, but it is not effective in a patient with accelerated humoral rejection occurring after transplantation.

Original languageEnglish
Pages (from-to)449-454
Number of pages6
JournalTherapeutic Apheresis
Volume5
Issue number6
DOIs
Publication statusPublished - 2001

Keywords

  • ABO incompatible
  • Crossmatch
  • Liver transplantation
  • Living donor

ASJC Scopus subject areas

  • Medicine(all)

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