Antibody-dependent cellular cytotoxicity in the immunotherapeutic mechanisms of anti-EGFR monoclonal antibody

Hideki Shimodaira, Keigo Komine, Hiroshi Soeda, Chikashi Ishioka

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

EGFR constitute an attractive target for tumor therapy, because it is a transmembrane receptor tyrosine kinase which is critically involved in tumorigenesis by stimulating cell proliferation and inhibiting apoptosis or other biological functions. The anti-tumor effects of targeted therapy by anti-EGFR monoclonal antibodies are mainly based on direct inhibition of the EGFR signal transduction pathway. In addition, monoclonal antibody has the potential advantage of recruiting immune effector mechanisms to kill tumor cells. The pre-dinical and clinical data indicated that antibody-dependent cellular cytotoxicity (ADCC) contributes to tumor cell lysis by anti-EGFR monoclonal antibodies. Some polymorphisms in Fc gamma receptor genes have been shown to be a predictive marker for the efficacy of anti-EGFR antibodies. Continued research on the immunotherapeutic mechanisms of monoclonal antibodies will improve the efficacy of antibody-based targeted therapy for cancer.

Original languageEnglish
Pages (from-to)795-798
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume37
Issue number5
Publication statusPublished - 2010 Jan 1

Keywords

  • ADCC
  • Anti-EGFR antibody

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

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