Antibiotic susceptibility survey of blood-borne MRSA isolates in Japan from 2008 through 2011

Hideaki Hanaki, Longzhu Cui, Yurika Ikeda-Dantsuji, Taiji Nakae, Junichi Honda, Katsunori Yanagihara, Yoshio Takesue, Tetsuya Matsumoto, Keisuke Sunakawa, Mitsuo Kaku, Kazunori Tomono, Kunihiko Fukuchi, Shinya Kusachi, Hiroshige Mikamo, Tohru Takata, Yoshihito Otsuka, Osanori Nagura, Shigeki Fujitani, Yosuke Aoki, Yoshio YamaguchiKazuhiro Tateda, Junichi Kadota, Shigeru Kohno, Yoshihito Niki

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28 Citations (Scopus)

Abstract

We conducted an antibiotic susceptibility survey of 830 blood-borne methicillin resistant Staphylococcus aureus collected from nationwide hospitals in Japan over a three-year period from January 2008 through May 2011. Antibiotic susceptibility was judged according to the criteria recommended by the Clinical Laboratory Standard Institute. Over 99% of the MRSA showed to be susceptible to teicoplanin, linezolid, sulfamethoxazole/trimethoprim and vancomycin, and over 97% of them were susceptible to daptomycin, arbekacin and rifampin. The majority of the MRSA strains showed resistant to minocycline, meropenem, imipenem, clindamycin, ciprofloxacin, cefoxitin, and oxacillin in the rates of 56.6, 72.9, 73.7, 78.7, 89.0, 99.5, and 99.9%, respectively. Among the MRSA strains, 72 showed reduced susceptibility to vancomycin, including 8 strains (0.96%) of vancomycin-intermediate S. aureus (VISA), 54 (6.51%) of heterogeneous vancomycin-intermediate S. aureus (hVISA), and 55 (5.63%) of β-lactam antibiotics-induced vancomycin resistant S. aureus (BIVR). Unexpectedly, among the 54 hVISA and 55 BIVR, 45 isolates (83.3% and 81.8%, respectively) showed both hVISA and BIVR phenotypes. A new trend of vancomycin resistance found in this study was that VISA strains were still prevalent among the bacteremic specimens. The high rates of the hVISA/BIVR two-phenotypic vancomycin resistance, and the prevalence of VISA in the bloodborne MRSA call attention in the MRSA epidemiology in Japan.

Original languageEnglish
Pages (from-to)527-534
Number of pages8
JournalJournal of Infection and Chemotherapy
Volume20
Issue number9
DOIs
Publication statusPublished - 2014 Sep

Keywords

  • Antibiotic susceptibility surveillance
  • Blood-borne MRSA
  • Heterogeneous VISA (hetero-VISA or hVISA)
  • MRSA
  • Vancomycin-intermediate Staphylococcus aureus (VISA)
  • β-lactam antibiotics-induced vancomycin resistant S. aureus (BIVR)

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Hanaki, H., Cui, L., Ikeda-Dantsuji, Y., Nakae, T., Honda, J., Yanagihara, K., Takesue, Y., Matsumoto, T., Sunakawa, K., Kaku, M., Tomono, K., Fukuchi, K., Kusachi, S., Mikamo, H., Takata, T., Otsuka, Y., Nagura, O., Fujitani, S., Aoki, Y., ... Niki, Y. (2014). Antibiotic susceptibility survey of blood-borne MRSA isolates in Japan from 2008 through 2011. Journal of Infection and Chemotherapy, 20(9), 527-534. https://doi.org/10.1016/j.jiac.2014.06.012