TY - JOUR
T1 - Antibacterial properties of Cu-doped TiO2 prepared by chemical and heat treatment of Ti metal
AU - Suzuki, Kanae
AU - Yokoi, Taishi
AU - Iwatsu, Misato
AU - Furuya, Maiko
AU - Yokota, Kotone
AU - Mokudai, Takayuki
AU - Kanetaka, Hiroyasu
AU - Kawashita, Masakazu
N1 - Funding Information:
This work was partially supported by JSPS KAKENHI [grant number: JP16H03177] and the Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University [Project ?Design & Engineering by Joint Inverse Innovation for Materials Architecture?] of the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
Publisher Copyright:
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The Korean Ceramic Society and The Ceramic Society of Japan.
PY - 2021
Y1 - 2021
N2 - In this study, we proposed Cu-doped TiO2, prepared by the alkaline and heat treatment of titanium (Ti) metal, for use in dental applications because of its bone-bonding and antibacterial properties generated by the release of Cu ions and visible-light-responsive photocatalysis. We successfully prepared Cu-doped TiO2 on a Ti chip surface with a Cu content of 7 at.%. The apatite-forming ability of the Cu-doped TiO2 was evaluated using a simulated body fluid and it was found that apatite formation occurred. Hence, we concluded that Cu-doped TiO2 exhibits bone-bonding properties. The antibacterial properties of Cu-doped TiO2 for Escherichia coli were higher than those of non-doped TiO2 under visible light irradiation. The enhanced antibacterial effect was mainly caused by the visible-light-responsive photocatalysis of Cu-doped TiO2. We confirmed that the reactive oxygen species generated by the visible-light-responsive photocatalysis of Cu-doped TiO2 were hydroxyl radicals formed by the reaction of hydroxide ions (OH−) and holes (h+). Our findings are useful for the development of novel bioactive TiO2-based coatings and bulk materials with antibacterial properties by Cu doping.
AB - In this study, we proposed Cu-doped TiO2, prepared by the alkaline and heat treatment of titanium (Ti) metal, for use in dental applications because of its bone-bonding and antibacterial properties generated by the release of Cu ions and visible-light-responsive photocatalysis. We successfully prepared Cu-doped TiO2 on a Ti chip surface with a Cu content of 7 at.%. The apatite-forming ability of the Cu-doped TiO2 was evaluated using a simulated body fluid and it was found that apatite formation occurred. Hence, we concluded that Cu-doped TiO2 exhibits bone-bonding properties. The antibacterial properties of Cu-doped TiO2 for Escherichia coli were higher than those of non-doped TiO2 under visible light irradiation. The enhanced antibacterial effect was mainly caused by the visible-light-responsive photocatalysis of Cu-doped TiO2. We confirmed that the reactive oxygen species generated by the visible-light-responsive photocatalysis of Cu-doped TiO2 were hydroxyl radicals formed by the reaction of hydroxide ions (OH−) and holes (h+). Our findings are useful for the development of novel bioactive TiO2-based coatings and bulk materials with antibacterial properties by Cu doping.
KW - Titanium dioxide
KW - antibacterial properties
KW - bone-bonding property
KW - copper doping
KW - visible-light-responsive photocatalysis
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U2 - 10.1080/21870764.2021.1979287
DO - 10.1080/21870764.2021.1979287
M3 - Article
AN - SCOPUS:85116699805
VL - 9
SP - 1448
EP - 1456
JO - Journal of Asian Ceramic Societies
JF - Journal of Asian Ceramic Societies
SN - 2187-0764
IS - 4
ER -