Antibacterial Activity of Tilmicosin against Pasteurella multocida and Actinobacillus pleuropneumonias Isolated from Pneumonic Lesions in Swine

Tamio Inamoto, Katsuaki Kikuchi, Hiroaki Iijima, Yasunaga Kawashima, Yutaka Nakai, Keiji Ogimoto

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Sixty one strains of Pasteurella multocida and 35 strains of Actinobacillus pleuropneumoniae isolated from pneumonic lesions of porcine lungs during the period from 1985 to 1989 in Japan were tested for antibiotic susceptibility to chlortetracycline (CTC), thiamphenicol (TP), tylosin (TS), acetylisovaleryl-tylosin (AIV-TS), tilmicosin (TMS), mirosamycin (MRM). Most strains of both species were sensitive to CTC, TP and TMS. Growth of fifty-one strains (83.6%) and forty-six strains (75.4%) of P. multocida were inhibited with 3.13 /xg/ml of CTC and 0.78 fig/ml of TP, respectively. TS showed low activity against almost all strains (MIC S 6.25 xg/ml). Fifty-eight (95.1%), twenty-three (37.7%) and fifty (82%) of P. multocida showed MICs of g 6.25 iiglml against AIV-TS, TMS and MRM, respectively. The MICs of A. pleuropneumoniae against CTC were less than 1.56 jug/m/. Thirty-two strains (91.4%) and 33 strains (94.3%) of A. pleuropneumoniae were inhibited with 3.13 g/m/ of TP and TMS respectively. However, TS, AIV-TS and MRM showed low activity against all of A. pleuropneumoniae (MIC i? 6.25 |U,g/m/). Three different resistance patterns were observed in P. multocida and two in A. pleuropneumoniae isolates, respectively.

Original languageEnglish
Pages (from-to)917-921
Number of pages5
JournalJournal of Veterinary Medical Science
Volume56
Issue number5
DOIs
Publication statusPublished - 1994

Keywords

  • Actinobacillus pleuropneumoniae
  • Pasteurella multocida
  • antibiotic susceptibility
  • swine
  • tilmicosin

ASJC Scopus subject areas

  • veterinary(all)

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