Antibacterial activity of KW-1070 against freshly isolated potential pathogens-comparison with other aminoglycosides

Seiichi Aonuma, Masako Sasaki, Kikuo Onuma, Akira Watanabe, Kotaro Oizumi, Kiyoshi Konno

    Research output: Contribution to journalArticlepeer-review

    Abstract

    In vitro antimicrobial activities of KW-1070, a new aminoglycoside antibiotic, against clinically isolated potential pathogens were examined with Dynatech MIC 2000. Following 206 strains of various species were included in this study; 19 of Stapylococcus aureus, 40 of Pseudomonas aeruginosa, 45 of Klebsiella pneumoniae, 41 of Escherichia coli, 16 of Serratia marcescens and 45 of Enterobacter spp. Minimum inhibitory concentrations against these strains were determined immediately on the day of the isolation of the microorganisms from clinical specimens. The three-month period of investigation lasted from December 1980 to February 1981. The results of determination of MICs of KW-1070 were compared with those of gentamicin, dibe-kacin, tobramycin and amikacin. It was found that KW-1070 showed more potent antimicrobial activities than other aminoglycosides with an exception of gentamicin. The effect of gentamicin on gram-negative bacilli was almost equal to or stronger than KW-1070. However, KW-1070 was not so effective as other aminoglycosides on Pseudomonas aeruginosa. No evident cross-sensitivity was found between KW-1070 and amikacin, especially when Serratia marcescens and Enterobacter spp. were used as test microbes.

    Original languageEnglish
    Pages (from-to)238-243
    Number of pages6
    JournalChemotherapy
    Volume29
    Issue numberS-2
    DOIs
    Publication statusPublished - 1981 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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