Antibacterial activity of carbapenems against clinically isolated respiratory bacterial pathogens in Japan between 2005 and 2006

Kazunori Gomi, Akira Watanabe, Shizuka Aoki, Toshiaki Kikuchi, Katsuhiro Fuse, Toshihiro Nukiwa, Iku Kurokawa, Shigeru Fujimura

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    The current status of the susceptibility of the main respiratory bacterial pathogens was evaluated by analysing the antibacterial activity of 21 drugs, including four carbapenems, against five species of the pathogens isolated between January 2005 and January 2006. A total of 157 strains were studied. Carbapenems inhibited the growth of all of the tested strains of Moraxella catarrhalis, Streptococcus pneumoniae and methicillin-susceptible Staphylococcus aureus strains at concentrations that were below the breakpoints set by the Japanese Society of Chemotherapy (2 and 1 μg/mL for pneumonia and chronic respiratory tract infection, respectively). However, the majority of methicillin-resistant Staphylococcus aureus strains were resistant to carbapenems. Meropenem, but not the other carbapenems, inhibited the growth of all of the tested strains of Haemophilus influenzae isolates, including β-lactamase-non-producing ampicillin-resistant strains, at concentrations of ≤1 μg/mL. The MIC50 and MIC90 of meropenem, 0.25 and 4 μg/mL, against Pseudomonas aeruginosa were the lowest of the carbapenems. By comparing these results with our previous data, it was found that there was no increase in resistance to carbapenems in any of the species tested. Thus, it can be stated that carbapenems have retained their position as key drugs for severe respiratory tract infections.

    Original languageEnglish
    Pages (from-to)586-592
    Number of pages7
    JournalInternational Journal of Antimicrobial Agents
    Volume29
    Issue number5
    DOIs
    Publication statusPublished - 2007 May 1

    Keywords

    • Antibacterial activity
    • Carbapenems
    • Japan
    • Respiratory pathogens

    ASJC Scopus subject areas

    • Microbiology (medical)
    • Infectious Diseases
    • Pharmacology (medical)

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