Antibacterial activity of carbapenems against clinical isolates of respiratory bacterial pathogens in the northeastern region of Japan in 2007

Kazunori Gomi, Shigeru Fujimura, Katsuhiro Fuse, Hidenari Takane, Yoshihisa Nakano, Yasuko Kariya, Toshiaki Kikuchi, Iku Kurokawa, Yutaka Tokue, Akira Watanabe

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

As the increasing prevalence of resistant strains of respiratory bacterial pathogens has recently been reported, continuous monitoring of the susceptibility of clinical isolates to antibacterial agents is important. We performed a surveillance study focusing on the susceptibility of major respiratory bacterial pathogens in the northeastern region of Japan to carbapenems and control drugs. A total of 168 bacterial strains isolated from patients with respiratory tract infections in 2007 were collected and the minimum inhibitory concentration (MIC) determined. MIC data were subjected to pharmacokinetic/pharmacodynamic analysis with Monte Carlo simulation to calculate the probability of achieving the target of time above MIC with each carbapenem. All Moraxella catarrhalis, Streptococcus pneumoniae, and methicillin-sensitive Staphylococcus aureus isolates were susceptible to carbapenems. Despite the increasing prevalence of β-lactamase-nonproducing ampicillin-resistant strains, all Haemophilus influenzae isolates were susceptible to meropenem. For Pseudomonas aeruginosa, the susceptibility rates for meropenem and biapenem were 76.7%, and the highest probability of achieving pharmacodynamic target (40% of the time above MIC) was obtained with meropenem 0.5 g three times daily as a 4-h infusion (89.4%), followed by meropenem 0.5 g four times daily as a 1-h infusion (88.4%). Carbapenems have retained their position as key drugs for severe respiratory tract infections.

Original languageEnglish
Pages (from-to)200-206
Number of pages7
JournalJournal of Infection and Chemotherapy
Volume17
Issue number2
DOIs
Publication statusPublished - 2011 Apr
Externally publishedYes

Keywords

  • Antibacterial susceptibility
  • Carbapenem
  • Respiratory tract infection (RTI)

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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