Antibacterial activity of Ag nanoparticle-containing hydroxyapatite powders in simulated body fluids with Cl ions

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In vitro dissolution and antibacterial activity of Ag nanoparticle-containing hydroxyapatite (HA) powders (AgNPHAP) synthesized by precipitation method were evaluated in this study. AgNPHAP were immersed in Tris-HCl solution with 30 mM Cl ions to estimate the in vitro dissolution behavior. The amount of Ag ions in Tris-HCl solution first increased and then decreased because Ag ions reacted with Cl ions to form AgCl. The antibacterial activity of AgNPHAP increased with increasing amounts of AgNPs attached to the HA powders in both 1/500 nutrient broth (NB) and undiluted NB solutions, which had Cl ion concentrations of 0.2 and 100 mM, respectively. These results indicate that HA powders as Ag nanoparticle carriers can effectively prevent bacterial infections despite AgCl precipitation, even under simulated biological conditions such as in undiluted NB solution.

Original languageEnglish
Pages (from-to)473-478
Number of pages6
JournalMaterials Chemistry and Physics
Volume223
DOIs
Publication statusPublished - 2019 Feb 1

Keywords

  • Antibacterial activity
  • Hydroxyapatite
  • In vitro dissolution
  • Silver chloride
  • Silver nanoparticle

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Antibacterial activity of Ag nanoparticle-containing hydroxyapatite powders in simulated body fluids with Cl ions'. Together they form a unique fingerprint.

Cite this