Anti-tumor effects of cavitation induced with phase-change nano droplet and ultrasound

Ken Ichi Kawabata, Rei Asami, Takashi Azuma, Hideki Yoshikawa, Shin Ichiro Umemura

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We performed a study to look into the therapeutic application of a novel diagnostic and therapeutic agent, phase change nano droplet (PCND), in combination with 1-MHz ultrasound. It was found using gel phantoms that PCND works as a cavitation accelerator for a 1-MHz ultrasound only when an ultrasound which changes the phase of PCND from liquid to gas (phase change ultrasound) is exposed in advance. A nano droplet that cannot change its phase to a gas does not work even in the presence of the phase change ultrasound. The cavitation induction with the aid of a PCND was observable by B-mode echography as a brightness change. Such a brightness change was also observed in in vivo experiments on tumor baring mice in the presence of a PCND and a phase change ultrasound. Moreover, tissue damage was observed at the site of the brightness change. The lack of either a PCND or a phase change ultrasound did not induce any brightness change, suggesting the same mechanism as a gel phantom works in living tissues. Our results are promising for use in a noble ultrasound therapy system with high selectivity and safety while improving the throughput of current ultrasound tumor treatment systems.

Original languageEnglish
Title of host publication2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages4
ISBN (Print)9781424443895
Publication statusPublished - 2009
Event2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy
Duration: 2009 Sep 202009 Sep 23

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117


Other2009 IEEE International Ultrasonics Symposium, IUS 2009

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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