Anti-ribosomal P antibodies and lupus nephritis

Ken Ichi Hosoya, Masanori Tachikawa

Research output: Contribution to journalReview articlepeer-review

47 Citations (Scopus)

Abstract

The blood-brain barrier (BBB) and blood- cerebrospinal fluid barrier (BCSFB) play key roles in the influx and efflux transport of endogenous substrates in the brain and cerebrospinal fluid. The organic anion transporter (OAT) 3 and organic cation transporter (OCT) 3, which belong to the solute carrier (SLC) 22A family, are expressed at the BBB and BCSFB, and regulate the excretion of endogenous and exogenous organic anions and cations. Our recent research provides novel molecular and functional evidence that indoxyl sulfate, an anionic uremic toxin, undergoes efflux transport at the BBB via OAT3 and creatinine, a uremic guanidino compound, undergoes efflux transport at the BCSFB via OCT3. Renal impairment is associated with the accumulation of uremic toxins in blood and uremic encephalopathy. It is conceivable that uremic encephalopathy is related to inhibition or dysfunction of efflux transport systems for uremic toxins in the brain. Here, we review the function of OAT3 and OCT3 at the BBB and BCSFB in the context of their roles in the progression of renal failure.

Original languageEnglish
Pages (from-to)478-485
Number of pages8
JournalClinical and experimental nephrology
Volume15
Issue number4
DOIs
Publication statusPublished - 2011 Aug
Externally publishedYes

Keywords

  • Blood-brain barrier
  • Blood-cerebrospinal fluid barrier
  • Creatinine
  • Indoxyl sulfate
  • Organic anion transporter
  • Organic cation transporter

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

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