Anti-MOG (myelin oligodendrocyte glycoprotein)-positive severe optic neuritis with optic disc ischaemia and macular star

Frederico Castelo Moura, Douglas Kazutoshi Sato, Carolina Medeiros Rimkus, Samira Luisa Apóstolos-Pereira, Luana Michelli De Oliveira, Claudia Costa Leite, Kazuo Fujihara, Mario Luiz Ribeiro Monteiro, Dagoberto Callegaro

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

A 44-year-old man presented with severe right visual loss. The right fundus examination showed marked optic disc oedema associated with partial macular star. Serological blood tests for infectious agents were all negative. Serum aquaporin-4 antibody was negative but anti-MOG (myelin oligodendrocyte glycoprotein) was positive. Magnetic resonance revealed extensive lesion in right optic nerve. There was no visual improvement after intravenous therapy. Patient had no further attacks after follow-up. Optic disc oedema with macular star is found in several infectious and non-inflammatory disorders, but it has not been reported in optic neuritis (ON) associated with autoantibodies to myelin oligodendrocyte glycoprotein (anti-MOG).

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalNeuro-Ophthalmology
Volume39
Issue number6
DOIs
Publication statusPublished - 2015 Jan 1

Keywords

  • Devic's syndrome
  • Macular star
  • Multiple sclerosis
  • Myelin oligodendrocyte glycoprotein antibody
  • Optic neuritis

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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