Anti-influenza virus compound from Streptomyces sp. RI18

Motoki Takagi, Keiichiro Motohashi, Aya Nagai, Miho Izumikawa, Masahiro Tanaka, Shinichiro Fuse, Takayuki Doi, Keiichiro Iwase, Atsushi Kawaguchi, Kyosuke Nagata, Takashi Takahashi, Kazuo Shin-Ya

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Screening for anti-influenza virus activity in compounds isolated from Streptomyces sp. RI18, which was isolated using the membrane filter method, uncovered a novel compound, JBIR-68 (1), which contains a unique skeleton. Its structure was established by extensive NMR and MS analyses. In addition, 1 was synthesized to confirm the configuration of its sugar moiety. Compound 1 inhibited influenza virus growth in plaque assays.

Original languageEnglish
Pages (from-to)4664-4666
Number of pages3
JournalOrganic letters
Volume12
Issue number20
DOIs
Publication statusPublished - 2010 Oct 15

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Takagi, M., Motohashi, K., Nagai, A., Izumikawa, M., Tanaka, M., Fuse, S., Doi, T., Iwase, K., Kawaguchi, A., Nagata, K., Takahashi, T., & Shin-Ya, K. (2010). Anti-influenza virus compound from Streptomyces sp. RI18. Organic letters, 12(20), 4664-4666. https://doi.org/10.1021/ol102007d