Anti-HTLV-III and anti-HTLV-I antibodies and T cell subsets in hemophiliacs living in HTLV-I endemic and nonendemic areas of Japan

T. Hattori, S. Ikematsu, T. Chosa, S. Yamamoto, M. Matsuoka, K. Fukutake, M. Robert-Guroff, K. Takatsuki

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6 Citations (Scopus)

Abstract

Sera from 154 hemophiliacs, including 132 with hemophilia A and 22 with hemophilia B, were examined for antibodies against human T cell lymphotropic virus type III (HTLV-III) and type I by strip radioimmunoassay based on the Western blotting technique. Sixty-two patients lived in Kyushu, a known endemic area of HTLV-I and 92 patients lived in Tokyo, a nonendemic area of HTLV-I. Results showed a prevalence of HTLV-III antibodies of 64.5% in Kyushu and of 57.6% in Tokyo. There were no significant differences between these two groups. Helper/suppressor (T4/T8) ratios of seropositive patients were 0.69 ± 0.41 and those of seronegative patients were 1.05 ± 0.56. Ratios of both groups were lower than those of normal healthy people (1.35 ± 0.45). Our findings confirmed that hemophiliacs living in an HTLV-I endemic area and those living in a nonendemic area in Japan equally possessed antibodies to HTLV-III. Low T4/T8 ratios and increases of serum IgG and IgM levels were found even in seronegative hemophiliacs.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalActa Haematologica
Volume77
Issue number1
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Hematology

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