Anti-Horse Podoplanin Monoclonal Antibody PMab-219 is Useful for Detecting Lymphatic Endothelial Cells by Immunohistochemical Analysis

Yukinari Kato, Shinji Yamada, Shunsuke Itai, Atsushi Kobayashi, Satoru Konnai, Mika K. Kaneko

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Podoplanin (PDPN) is expressed in lymphatic endothelial cells, where it induces platelet aggregation through C-type lectin-like receptor-2 (CLEC-2). This protein has been characterized for a number of animal species using specific anti-PDPN monoclonal antibodies (mAbs). We recently established the mAb against horse PDPN (horPDPN) named PMab-219. Therefore, in this study, we investigated whether PMab-219 can detect lymphatic endothelial cells in horse tissues. Immunohistochemical analysis demonstrated that PMab-219 strongly stained lymphatic endothelial cells in horse colon tissues, indicating that it will be useful for investigating the function of horPDPN in these cells.

Original languageEnglish
Pages (from-to)272-274
Number of pages3
JournalMonoclonal antibodies in immunodiagnosis and immunotherapy
Volume37
Issue number6
DOIs
Publication statusPublished - 2018 Dec

Keywords

  • PDPN
  • PMab-219
  • horse podoplanin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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