Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus

C. Pupilli, A. Antonelli, L. Iughetti, G. D'Annunzio, M. Cotellessa, M. Vanelli, H. Okamoto, R. Lorini, Ele Ferrannini

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aims: To test for anti-CD38 autoimmunity in children with newly-diagnosed type 1 diabetes mellitus (DM1). Methods: Serum anti-CD38 autoantibodies were detected by Western blot in 270 children (130 girls, 140 boys, mean age 8 ± 4 years) with newly-diagnosed DM1. and 179 gender- and age-matched non-diabetic children. In 126 diabetic children, another blood sample was obtained 15 ± 4 months after the diagnosis. Results: Anti-CD38 autoantibody titers at least 3 SD above the mean value for the control group were found in 4.4% of children with DM1 vs 0.6% of controls (χ2 = 5.8, p <0.016). No statistical differences were observed between anti-CD38 positive and negative patients in terms of phenotype. At follow-up, of six diabetic children who were positive for anti-CD38 antibodies, two were new cases. A positive correlation was found between the antibody titer of diabetic sera at diagnosis and follow up (r = 0.46, p <0.0001). Conclusion: An autoimmune reaction against CD38, a protein expressed in human islets, is associated with newly-diagnosed DM1. In children with DM1, CD38 autoimmunity increases with time and persists.

Original languageEnglish
Pages (from-to)1417-1423
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume18
Issue number12
DOIs
Publication statusPublished - 2005 Dec

Keywords

  • CD38 antibodies
  • Children
  • GAD antibodies
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus'. Together they form a unique fingerprint.

  • Cite this

    Pupilli, C., Antonelli, A., Iughetti, L., D'Annunzio, G., Cotellessa, M., Vanelli, M., Okamoto, H., Lorini, R., & Ferrannini, E. (2005). Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus. Journal of Pediatric Endocrinology and Metabolism, 18(12), 1417-1423. https://doi.org/10.1515/JPEM.2005.18.12.1417