Abstract
Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system that is associated with a serum anti-aquaporin 4 (AQP4) autoantibody. A commercial-based anti-AQP4 antibody detection system using an enzyme-linked immunosorbent assay (ELISA) has recently become available in Japan. Because this ELISA has low sensitivity, a more sensitive cell-based assay is required in some cases. Some seronegative patients with NMO are reported positive for the anti-myelin oligodendrocyte glycoprotein (MOG) antibody. Because anti-MOG antibody is known to be associated with pediatric acute disseminated encephalomyelitis (ADEM), it is of great interest to determine whether anti-MOG antibody-positive NMO is in the same spectrum as ADEM. Moreover, many adult patients with idiopathic optic neuritis (ON) are positive for the anti-MOG antibody. We suggest that anti-MOG antibody-positive ON tends to occur more frequently in male patients and tends to be milder than anti-AQP4 antibody-positive ON.
Original language | English |
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Pages (from-to) | 128-134 |
Number of pages | 7 |
Journal | Neuro-Ophthalmology Japan |
Volume | 32 |
Issue number | 2 |
Publication status | Published - 2015 |
Keywords
- Anti-aquaporin 4 antibody
- Anti-myelin oligodendrocyte glycoprotein antibody
- Cell-based assay
- Neuromyelitis optica
- Optic neuritis
ASJC Scopus subject areas
- Ophthalmology
- Clinical Neurology