Anti-angiogenic activity of tocotrienol

Hitoshi Inokuchi, Hisako Hirokane, Tsuyoshi Tsuzuki, Kiyotaka Nakagawa, Miki Igarashi, Teruo Miyazawa

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with δ-tocotrienol appearing the highest activity. Also, δ-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. Our findings suggest that tocotrienol has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis.

Original languageEnglish
Pages (from-to)1623-1627
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume67
Issue number7
DOIs
Publication statusPublished - 2003 Jan 1

Keywords

  • Angiogenesis inhibitor
  • Cancer
  • Tocopherol
  • Tocotrienol
  • Vitamin E

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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