Antagonism between bisphosphonates (BPs) and structurally related substances in the effects of BPs in mice

Satoru Okada, Tomomi Kiyama, Takefumi Oizumi, Kouji Yamaguchi, Hiroshi Kawamura, Shunji Sugawara, Yasuo Endo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The anti-bone-resorptive effects (ABREs) of nitrogen-containing BPs (NBPs) are much more powerful than those of non-nitrogen-containing BPs (nonNBPs). However, NBPs have inflammatory and necrotic side effects (INSEs) including osteonecrosis of jaw bones. Here, we examined antagonism between BPs and structurally related substances in terms of ABREs and INSEs. Our findings suggest that a certain type(s) of transporters or related mechanisms may be involved in the intracellular uptake of NBPs, leading to INSEs.

Original languageEnglish
Title of host publicationInterface Oral Health Science 2011
PublisherSpringer Japan
Pages235-236
Number of pages2
ISBN (Electronic)9784431540700
ISBN (Print)9784431540694
DOIs
Publication statusPublished - 2012 Jan 1

Keywords

  • Bisphosphonate
  • Clodronate
  • Etidronate
  • Osteonecrosis
  • Zoledronate

ASJC Scopus subject areas

  • Dentistry(all)

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