Annulation of α,β-unsaturated imines and alkynes via cobalt-catalyzed olefinic C-H activation

Takeshi Yamakawa, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

A cobalt-triarylphosphine catalyst promotes an annulation reaction of an α,β-unsaturated imine and an internal alkyne to afford a polysubstituted dihydropyridine derivative in good yield under mild conditions. The reaction likely involves alkenylation of the olefinic C-H bond via cobalt-mediated nitrogen-assisted C-H activation followed by facile 6π electrocyclization of the resulting azatriene intermediate.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalOrganic letters
Volume15
Issue number1
DOIs
Publication statusPublished - 2013 Jan 4
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Annulation of α,β-unsaturated imines and alkynes via cobalt-catalyzed olefinic C-H activation'. Together they form a unique fingerprint.

Cite this