Annual change of ofloxacin-resistace in clinical isolates of bacteria

Hiroko Ishida, Masato Hohmura, Kenichi Sato, Isao Hayakawa, Yasuaki Osada, Hideki Ohtani, Hiroshi Uchida, Koichi Deguchi, Kazuo Chiba, Jun Ichi Chiba, Akira Watanabe

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)


    Twelve species (4, 404 strains) of clinical isolates of bacteria were collected from 6 institutes during a five-year period from 1987 to 1991. We determined the susceptibility to ofloxacin and compared it with that to other antimicrobial agents. There were no significant changes in the MICsoS of ofloxacin for any of the 12 species tested, though the MICso s for Staphylococcus aureus, Coagulase -negative staphylococci and Pseudomonas aeruginosa increased. Similar results were observed with ciprofloxacin and the other quinolones tested. The isolation frequency of metoicillin-resisntant S. aureus (MRSA) among 5. aureus in 1987 was almost the same as that in 1991, but that of ofloxacin -resistant s. aureus among MRSA increased considerably from 27% to 72%.

    Original languageEnglish
    Pages (from-to)740-749
    Number of pages10
    Issue number7
    Publication statusPublished - 1993

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology


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