Anionic liposome template synthesis of raspberry-like hollow silica particle under ambient conditions with basic catalyst

Haruyuki Ishii, Kumi Sato, Daisuke Nagao, Mikio Konno

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hollow silica particle was obtained with a vesicle template synthesis in water under ambient conditions in the presence of ammonia. Biomimetic vesicles, liposomes were used, which consisted of a zwitterionic phospholipid, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), and a tiny amount of charged amphiphiles, hexadecylamine (HDA) or dicetylphosphate (DCP). Aggregation of silica occurred for DPPC or cationic DPPC/HDA liposome, whereas well-dispersed hollow silica particle could be obtained for anionic DPPC/DCP liposome. The hollow particle synthesized with the anionic liposome had single-layered and raspberry-like structures. Electrostatic repulsion between anionic vesicles maintained stable dispersion of the as-synthesized particles during the reaction. Formation of the raspberry-like morphology is explained by silica particle precipitation selectively induced around the liposomes under basic conditions due to affinity of silica precursors for the liposomes. Synthesis of well-dispersed hollow silica particle with a raspberry-like morphology is the first report in vesicle template syntheses.

Original languageEnglish
Pages (from-to)372-376
Number of pages5
JournalColloids and Surfaces B: Biointerfaces
Volume92
DOIs
Publication statusPublished - 2012 Apr 1

Keywords

  • Anionic liposome
  • Basic catalyst
  • Raspberry-like hollow silica particle
  • Vesicle template synthesis

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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