Animal Models of Vasculitis

Masato Nose

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Animal models of vasculitis have been key to clarifying the mechanisms underlying the development of vasculitis, and models have been generated of the different pathologic prototypes based on cellular, molecular and genetic events. Inductive and reductive trials have been performed to establish vasculitis models, in which the significant roles of immune complexes, the adaptive immunity against vascular components, antineutrophil cytoplasmic antibodies, cytokines, particular infections agents, autoimmunity and polygenes on the development of vasculitis were examined. Further hypothesis generation and testing using animal models will be required to completely elucidate the mechanisms underlying the development, progression and resolution of vasculitis.

Original languageEnglish
Title of host publicationInflammatory Diseases of Blood Vessels
Subtitle of host publicationSecond Edition
PublisherWiley-Blackwell
Pages115-125
Number of pages11
ISBN (Print)9781444338225
DOIs
Publication statusPublished - 2012 May 3

Keywords

  • Adaptive immunity
  • Autoimmunity
  • Chemokines
  • Cytokines
  • Immune complexes
  • Infectious agents
  • Innate immunity
  • Polygenes

ASJC Scopus subject areas

  • Medicine(all)

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