Animal Models for the Study of Infection-Associated Preterm Birth

Matthew W. Kemp, Gabrielle C. Musk, Masatoshi Saito

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

In industrialized and developing countries, preterm birth (live delivery before 39 weeks of gestation) is both a leading cause of neonatal death and a major risk factor for respiratory, neurological, and cognitive disabilities in those infants who survive to adolescence. Intrauterine infection is considered a leading cause of preterm birth; data from clinical and experimental studies suggest that in utero infection accounts for upward of 40% of preterm deliveries.This chapter is written with two aims: the first is to provide the reader with an introduction to infection-associated preterm birth, highlighting the importance of animal-based studies in the development of this field; and the second, adopting a practical focus, is designed to provide the reader with technical insight into the use of sheep as a model organism for the study of fetal inflammatory responses to the presence of microbial agonist in the uterine sphere.

Original languageEnglish
Title of host publicationAnimal Models for the Study of Human Disease
PublisherElsevier Inc.
Pages863-888
Number of pages26
ISBN (Print)9780124158948
DOIs
Publication statusPublished - 2013 Jul

Keywords

  • Animal model
  • Infection
  • Inflammation
  • Preterm birth
  • Sheep

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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