Animal models for intractable vasculitis: significance of genetic background

M. R. Ito, M. Nose

Research output: Contribution to journalReview articlepeer-review

Abstract

Almost all of intractable vasculitis have been thought to develop mainly in immunological mechanisms, based on the data from several animal models previously established. Serum sickness models, microbe-induced models and others have contributed to supporting this idea. These models have furthermore indicated that vasculitis could be generated by exogenous factors in normal individuals, and that vasculitis might be explained in monism. However, recent studies in murine lupus suggest that intractable vasculitis requires endogenous factors involving retroviruses and/or genetic background under the control of polygene system. In this review, although not comprehensive, significance of background genes in vasculitis will be focused.

Original languageEnglish
Pages (from-to)1982-1986
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Volume52
Issue number8
Publication statusPublished - 1994 Aug

ASJC Scopus subject areas

  • Medicine(all)

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