Angiotensin-converting enzyme I/D polymorphism and hypertension: The Ohasama study

Mitsunobu Matsubara, Michiko Suzuki, Tohru Fujiwara, Masahiro Kikuya, Hirohito Metoki, Mari Michimata, Tsutomu Araki, Itsuro Kazama, Tomomi Satoh, Junichiro Hashimoto, Atsushi Hozawa, Takayoshi Ohkubo, Ichiro Tsuji, Tomohiro Katsuya, Jitsuo Higaki, Toshio Ogihara, Hiroshi Satoh, Yutaka Imai

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)


Objective: Angiotensin-converting enzyme (ACE) I/D polymorphism in intron 16 of the ACE gene was analyzed in a general Japanese population in relation to self-blood pressure (BP) measurement at home (home BP) and ambulatory BP monitoring (ABPM) to determine the association between genetic variants of this polymorphism and hypertension. Design: A cross-sectional study. Methods and results: We genotyped the ACE I/D polymorphism in 1245 subjects with home BP and 803 subjects with ABPM in Ohasama, a rural community in Japan. All the subjects were 40 years of age and over, and gave written informed consent for the present genetic analysis. Hypertensive subjects were defined as those receiving antihypertensive drugs and those who had a home BP higher than 135 mmHg in systole and/or higher than 85 mmHg in diastole. The frequencies of the II, ID, and DD genotypes in these Japanese subjects were 0.45, 0.45, and 0.10, indicating a lower frequency of the D allele (0.33) than in Caucasians. There was no significant difference of BP level, prevalence of hypertension or nocturnal decline in BP among the genotypes. There were no differences in the prevalence of previous cardiovascular disease, age, body mass index, male gender, smoking, or biochemical and hormonal parameters among the three genotypes. Conclusion: The present results indicate the absence of direct effects of the ACE D-allele on BP level, prevalence of hypertension, prevalence of cardiovascular disease, and circadian BP variation. We conclude there is little association between ACE I/D polymorphism and hypertension in the general Japanese population.

Original languageEnglish
Pages (from-to)1121-1126
Number of pages6
JournalJournal of hypertension
Issue number6
Publication statusPublished - 2002 Jun


  • Ambulatory blood pressure monitoring
  • Circadian blood pressure variation
  • Home blood pressure measurement
  • Hypertension prevalence

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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