Angiopoietin-3, a novel member of the angiopoietin family

Motoi Nishimura, Takashi Miki, Rei Yashima, Norihide Yokoi, Hideki Yano, Yasufumi Sato, Susumu Seino

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)254-256
Number of pages3
JournalFEBS Letters
Volume448
Issue number2-3
DOIs
Publication statusPublished - 1999 Apr 9
Externally publishedYes

Keywords

  • Angiogenesis
  • Angiopoietin
  • Tie
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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