Angiogenesis derived from shear stress optimised by a microfruidic device

Yukako Teraoka, Masamune Nakayama, Yuji Nashimoto, Akiko Nakamasu, Sanshiro Hanada, Yuichiro Arima, Yu Suke Torisawa, Hidetoshi Kotera, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Previously, we created a 3D vascular network in a microfluidic device and demonstrated that the luminal flow significantly enhanced the formation of angiogenic sprouts as compared to static conditions [1]. These results could not be explained based on either biochemical factors (oxygen and nutrient transport) or mechanical factors (pressure and shear stress) derived angiogenesis. In this study, we investigated the effect of flow rate and shear stress on angiogenesis induced by luminal flow. We calculated the shear stress exposed on the endothelium where new sprouting initiated. Our results showed that angiogenesis was induced in the specific range of shear stress.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages1072-1073
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2020 Jan 1
Externally publishedYes
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 2017 Oct 222017 Oct 26

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period17/10/2217/10/26

Keywords

  • Angiogenesis
  • Microfluidic device
  • Shear stress
  • Vascular networks

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Teraoka, Y., Nakayama, M., Nashimoto, Y., Nakamasu, A., Hanada, S., Arima, Y., Torisawa, Y. S., Kotera, H., Nishiyama, K., Miura, T., & Yokokawa, R. (2020). Angiogenesis derived from shear stress optimised by a microfruidic device. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1072-1073). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.