Angiocentric glioma and surrounding cortical dysplasia manifesting as intractable frontal lobe epilepsy

Shihomi Takada, Masaki Iwasaki, Hiroyoshi Suzuki, Nobukazu Nakasato, Toshihiro Kumabe, Teiji Tominaga

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

A 26-year-old man presented with a case of angiocentric glioma manifesting as medically refractory epilepsy. Magnetic resonance imaging revealed a hyperintense lesion in the right superior frontal gyrus on T2-weighted imaging, with cortical hyperintense rim on T1-weighted images and minimum contrast enhancement. Video-electroencephalography (EEG) monitoring characterized his seizures as originating from the right frontal lobe. Long-term EEG recording from implanted subdural electrodes disclosed epileptic activities extending beyond the margin of the radiological lesion. Extended cortical resection of the superior frontal gyrus including the tumor and the surrounding epileptic cortices was performed. Postoperatively, he became seizure-free with antiepileptic medication during a 12-month follow-up period. Histological examination of the surgical specimen showed the characteristic findings of angiocentric glioma. Associated cortical dyslamination consistent with cortical dysplasia was found in the surrounding cortex. Angiocentric glioma is a slow-growing or stable tumor frequently presenting with intractable epilepsy. Surgical treatment would be aimed primarily at control of epilepsy. Complete lesionectomy usually results in postoperative seizure freedom, but the present case shows evidence for associated cortical dysplasia with this tumor entity. Careful pre-surgical evaluation for epilepsy is necessary to achieve better seizure outcome.

Original languageEnglish
Pages (from-to)522-526
Number of pages5
JournalNeurologia medico-chirurgica
Volume51
Issue number7
DOIs
Publication statusPublished - 2011 Jul

Keywords

  • Angiocentric glioma
  • Cortical dysplasia
  • Epilepsy surgery
  • Intractable epilepsy
  • Seizure

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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