Anesthesia in patients with cancer disorders

Shin Kurosawa

    Research output: Contribution to journalReview articlepeer-review

    53 Citations (Scopus)

    Abstract

    Purpose of review: Along with the increasing population of elderly people in developed countries, anesthesiologists have increasing opportunities to anesthetize cancer patients in their routine work. However, no guideline of anesthesia procedures for cancer patients is available even though guidelines of operative procedures have been formulated for different types of cancer. This review provides Recent findings related to the optimal choice of anesthetics and adequate anesthesia management for cancer patients. Recent findings: The intrinsic weapon fighting cancer cells is competent immune cells, particularly CD4 + T helper 1-type cells, CD8 + cytotoxic T cells, and natural killer cells. However, surgical inflammation, some anesthetics, and inadvertent anesthesia management suppress these effector cells and induce suppressive immune cells, which render cancer patients susceptible to tumor recurrence and metastasis after surgery. Summary: Accumulated basic and clinical data suggest that total intravenous anesthesia with propofol, cyclooxygenase antagonists, and regional anesthesia can decrease negative consequences associated with perioperative immunosuppression. Volatile anesthesia, systemic morphine administration, unnecessary blood transfusions, intraoperative hypoxia, hypotension, hypothermia, and hyperglycemia should be avoided.

    Original languageEnglish
    Pages (from-to)376-384
    Number of pages9
    JournalCurrent Opinion in Anaesthesiology
    Volume25
    Issue number3
    DOIs
    Publication statusPublished - 2012 Jun

    Keywords

    • anesthesia
    • cancer
    • immunosuppression
    • surgery

    ASJC Scopus subject areas

    • Anesthesiology and Pain Medicine

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