Analytical and experimental studies on the measurement of soft biological tissue elasticity using a pipette with rectangular cross section

Toshiro Ohashi, Hironobu Abe, Takeo Matsumoto, Takahira Aoki, Masaaki Sato

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

A pipette aspiration technique has been developed to clarify the local anisotropic stiffness of soft biological tissues. This technique provides a simple and practical method of measuring an initial elastic modulus by comparing the slope of the pressure-deformation curve obtained from a finite element analysis with that obtained by experiment using a pipette to aspirate the tissue surface. In previous studies, linear numerical simulations were performed for circular cross-sectional pipettes using an axisymmetric model that is assumed to be isotropic and homogeneous. In this paper, the use of rectangular cross-sectional pipettes was proposed to parametrically evaluate the effects of anisotropic properties of living tissues on the measurement of their stiffness. The calculated results indicated that rectangular pipettes eliminated the effect of the modulus parallel to the pipette major axis. The aspiration technique with a rectangular cross-sectional pipette should be effective for clarifying the anisotropy of biological tissues. Experimental verification of this technique was performed for the canine ligamentum nuchae.

Original languageEnglish
Pages (from-to)867-874
Number of pages8
JournalNippon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C
Volume63
Issue number607
DOIs
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Mechanics of Materials
  • Mechanical Engineering
  • Industrial and Manufacturing Engineering

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