Analysis of transfer characteristics of the autonomic nervous system information for the control of artifitial heart

In order to evaluate control characteristics of the circulatory system, frequency and cross correlation analyses of several parameters, i.e., heart rate(HR), aortic pressure(AOP) and peripheral vascular resistance(R), of circulatory systems driven by natural heart and by total artificial heart(TAH) have been carried out. As the result of these analyses, Mayer wave fluctuation from the circulatory system driven by TAH without heart rate variability has been observed. This suggests that the fluctuation may have its source in the AOP - R loop. The effect of AOP - HR loop on suppression of mutual variability between AOP and R has been also clarified through comparison between two groups of data with TAH and without TAH.