To realize the multivariable control of the circulatory system driven by the left ventricular assist device (LVAD), the responses of the circulatory system to the control inputs of the pneumatic drive unit has been analysed. The results from the mock circulatory system revealed that manipulation of the systolic duration (w) and the systolic delay (τ) enables us to control the outflow from the LVAD (LVADF) and the aortic pressure (AOP) independently to a certain degree. In the case of the adult goats whose cardiac functions were supressed by Inderal (propranolol), LVADF and AOP could be controlled by changing τ. However, the effect of the variation of w or τ on the cardiovascular dynamics was smaller than that of the mock system. This might be caused by a compensatory mechanism of the cardiovascular system using the neuronal and humoral feedback.
|Number of pages||8|
|Journal||japanese journal of medical electronics and biological engineering|
|Publication status||Published - 1990|
ASJC Scopus subject areas
- Biomedical Engineering