Analysis of the p53 gene mutations in patients with multiple primary cancers of the oesophagus

Takato Mayama, Takahiro Mori, Keiji Abe, Hironobu Sasano, Tetsuro Nishihira, Susumu Satomi, Akira Horii

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

We investigated genetic alterations of the p53 gene in two patients with multiple primary oesophageal squamous cell carcinomas (ESCs). We found that each primary tumour could be distinguished by mutation of p53. Moreover, mutations detected in the p53 gene in metastatic lymph nodes were the same as those detected in at least one of the primary tumours. Our results presented the possibility of: (1) discrimination of primary and metastatic legions in patients with multiple primary ESCs; (2) determination of metastatic pathway to regional lymph nodes; and (3) application for the development of a better clinical management of patients with multiple primary ESCs.

Original languageEnglish
Pages (from-to)298-303
Number of pages6
JournalEuropean Journal of Surgical Oncology
Volume23
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • Metastasis
  • Oesophageal multiple cancer
  • PCR-SSCP
  • p53

ASJC Scopus subject areas

  • Surgery
  • Oncology

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