Analysis of plasma protein concentrations and enzyme activities in cattle within the ex-evacuation zone of the Fukushima Daiichi Nuclear Plant Accident

Yusuke Urushihara, Koh Kawasumi, Satoru Endo, Kenichi Tanaka, Yasuko Hirakawa, Gohei Hayashi, Tsutomu Sekine, Yasushi Kino, Yoshikazu Kuwahara, Masatoshi Suzuki, Motoi Fukumoto, Hideaki Yamashiro, Yasuyuki Abe, Tomokazu Fukuda, Hisashi Shinoda, Emiko Isogai, Toshiro Arai, Manabu Fukumoto

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13 Citations (Scopus)

Abstract

The effect of the Fukushima Daiichi Nuclear Power Plant (FNPP) accident on humans and the environment is a global concern. We performed biochemical analyses of plasma from 49 Japanese Black cattle that were euthanized in the ex-evacuation zone set within a 20-km radius of FNPP. Among radionuclides attributable to the FNPP accident, germanium gamma-ray spectrometry detected photopeaks only from 134Cs and 137Cs (radiocesium) commonly in the organs and in soil examined. Radioactivity concentration of radiocesium was the highest in skeletal muscles. Assuming that the animal body was composed of only skeletal muscles, the median of internal dose rate from radiocesium was 12.5 μGy/day (ranging from 1.6 to 33.9 μGy/day). The median of external dose rate calculating from the place the cattle were caught was 18.8 μGy/day (6.0-133.4 μGy/day). The median of internal and external (total) dose rate of the individual cattle was 26.9 μGy/day (9.1-155.1 μGy/day). Plasma levels of malondialdehyde and superoxide dismutase activity were positively and glutathione peroxidase activity was negatively correlated with internal dose rate. Plasma alanine transaminase activity and percent activity of lactate dehydrogenase (LDH)-2, LDH-3 and LDH-4 were positively and LDH-1 was negatively correlated with both internal and total dose rate. These suggest that chronic exposure to low-dose rate of ionizing radiation induces slight stress resulting in modified plasma protein and enzyme levels.

Original languageEnglish
Article numbere0155069
JournalPloS one
Volume11
Issue number5
DOIs
Publication statusPublished - 2016 May 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Urushihara, Y., Kawasumi, K., Endo, S., Tanaka, K., Hirakawa, Y., Hayashi, G., Sekine, T., Kino, Y., Kuwahara, Y., Suzuki, M., Fukumoto, M., Yamashiro, H., Abe, Y., Fukuda, T., Shinoda, H., Isogai, E., Arai, T., & Fukumoto, M. (2016). Analysis of plasma protein concentrations and enzyme activities in cattle within the ex-evacuation zone of the Fukushima Daiichi Nuclear Plant Accident. PloS one, 11(5), [e0155069]. https://doi.org/10.1371/journal.pone.0155069