Analysis of patients with locally advanced gastric cancer undergoing gastrectomy after pre-operative chemotherapy including S-1

Makoto Kinouchi, Chikashi Shibata, Koh Miura, Mitsunori Okabe, Toshinori Andou, Masayuki Kakyou, Fumito Saijou, Sho Haneda, Hitoshi Ogawa, Michiaki Unno, Iwao Sasaki

Research output: Contribution to journalArticlepeer-review

Abstract

To improve the prognosis of advanced gastric cancer, various adjuvant therapies were tried. We retrospectively examined 7 cases of gastrectomy after pre-operative chemotherapy using S-1 +CDDP, and reported its effectiveness and the result. An adverse event of more than Grade 3 showed neutropenia in two cases. Anti-tumor effect on the imaging was found in 6 cases of PR and one case of SD. We performed gastrectomy within 4 weeks after completion of chemotherapy in each case. The histological antitumor effect was more than Grade 2 in four cases, but there was no complete response. We compared the overall survival of a patient of more than Grade 2 by histological antitumor effect under grade 1 b. In the former, MST was 982 days and the two-year survival rate was 50.0%; in the latter, MST was 443 days and the two-year survival rate was 33.3%. We can perform pre-operative chemotherapy using S-1+CDDP and expect prognostic improvement for a histologically effective case of chemotherapy. If the utility of preoperative chemotherapy mainly with S-1 is proved in a phase III trial, this would appear to be a therapy of choice for advanced gastric cancer in future.

Original languageEnglish
Pages (from-to)1481-1484
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume36
Issue number9
Publication statusPublished - 2009 Sep

Keywords

  • Advanced gastric cancer
  • Neo-adjuvant chemotherapy
  • S-1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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