Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Müllerian duct cells using microarray

Yasuhiro Miki, Takashi Suzuki, Chika Tazawa, Masato Ishizuka, Shuho Semba, Itsuo Gorai, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The Müllerian ducts are strongly influenced by natural estrogen, estradiol (E2) and diethylstilbestrol (DES) in their development. We screened E2 and DES responsive genes using a microarray analysis in human primitive Müllerian duct cell line, EMTOKA cells expressed estrogen receptor (ER) β. c-myc oncogene and other target genes expression was detected in cells treated by high-dose DES, but ER antagonist ICI 182,780 could not prevent c-myc induction above. Results of our present study suggested the presence of ER independent pathway in oncogenes induction process by high-dose DES treatment in a human primitive Müllerian duct cell line.

Original languageEnglish
Pages (from-to)197-210
Number of pages14
JournalCancer Letters
Volume220
Issue number2
DOIs
Publication statusPublished - 2005 Apr 8

Keywords

  • Diethylstilbestrol (DES)
  • Estradiol
  • Microarray
  • Müllerian duct cell
  • c-myc

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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