Abstract
The incidence of gene amplification in leukemia/lymphoma is significantly lower than that in solid tumors. For understanding the biological characteristics of leukemia/lymphoma, it is necessary to clarify whether the incidence of gene amplification is actually lower or gene amplification specific to hemopoietic malignancies has not yet been found. We describe a new version of in-gel DNA renaturation technique for general screening of gene amplification that allows detection and cloning of amplified genes of unknown nature as few as 7- to 8-fold amplification.
| Original language | English |
|---|---|
| Pages (from-to) | 1463-1470 |
| Number of pages | 8 |
| Journal | Acta Haematologica Japonica |
| Volume | 52 |
| Issue number | 8 |
| Publication status | Published - 1989 Dec 1 |
ASJC Scopus subject areas
- Hematology