Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis

Tomohiro Kaneta, Nobuyuki Okamura, Akira Arai, Kentaro Takanami, Katsutoshi Furukawa, Manabu Tashiro, Shozo Furumoto, Ren Iwata, Shoki Takahashi, Hiroyuki Arai, Kazuhiko Yanai, Yukitsuka Kudo

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Purpose: To examine the usefulness of the early phase [11C]BF- 227 positron emission tomography (PET) for (1) conferring additional diagnostic value by providing perfusion-like information and (2) obtaining the appropriate anatomical standardization (AS) using three-dimensional stereotactic surface projection (3D-SSP) method. Methods: This study included 20 mild cognitive impairment (MCI), 19 Alzheimer's disease (AD), and 17 normal cognitive (NC) subjects. Early- and late-phase BF-227 PET images were obtained 0-10 and 40-60 min after the injection, respectively. AS for late-phase BF-227 images were performed by 2 methods: (1) method A, for AS of late-phase BF-227 images using 8F-fluorodeoxyglucose (FDG) images of the same subject and (2) method B, for AS of late-phase BF-227 images using early phase BF-227 images. Results: Method B was successfully used for AS in all cases. The Z score maps of 3D-SSP analyses of FDG PET and early phase BF-227 PET for AD and MCI groups showed a typical AD-like pattern. Regional analyses revealed that the early phase BF-227 PET showed significant differences between AD and NC, and MCI and NC. Conclusion: The early phase BF-227 PET images showed significant abnormal findings for the AD and MCI groups. AS of late-phase BF-227 images using early phase BF-227 images were successful, and enabled appropriate 3D-SSP analyses.

Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalJapanese Journal of Radiology
Volume32
Issue number3
DOIs
Publication statusPublished - 2014 Mar

Keywords

  • 3D-SSP
  • Alzheimer's disease
  • Amyloid imaging
  • BF-227
  • Early phase

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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