Analysis of a shared pancreatic cancer antigen recognized by an hla-a*2601-restricted cytotoxic t-lymphocyte clone

Kiyoteru Kashiwagi, Hideyuki Ikeda, Yoshihiko Hirohashi, Masayuki Yamamoto, Satomi Idenoue, Itaru Hirai, Kenjiro Kamiguchi, Yasuaki Tamura, Toshiko Torigoe, Yshimasa Wada, Koichi Hirata, Noriyuki Sato

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Introduction We have generated HLA-A*2601-restricted CD8+CTL clones against an autologous pancreatic cancer cell line. Aims To characterize the antigen expressed on the cancer cells. Methodology We assessed cytotoxic activities and cytokine production of these CTL clones reacting against cancer cell lines that stably or transiently expressed the HLA-A*2601 gene. Results These CTL clones recognized 4 of 10 allogeneic pancreatic cancer cell lines and a gallbladder cancer cell line in the context of HLA-A*2601. However, the CTL clones did not recognize three hepatocellular carcinoma cell lines, two esophageal squamous cell carcinoma cell lines, or a lung adenocarcinoma cell line. Conclusions Thus, the CTL clones may recognize a shared, but not ubiquitously expressed, tumor antigen on pancreatic and gallbladder cancer cells.

Original languageEnglish
Pages (from-to)e81-e88
JournalNursing
Volume26
Issue number4
Publication statusPublished - 2003 May
Externally publishedYes

Keywords

  • CTL clone
  • Cancer antigen
  • HLA-A26
  • Pancreatic cancer

ASJC Scopus subject areas

  • Emergency
  • Critical Care
  • Assessment and Diagnosis
  • Advanced and Specialised Nursing
  • LPN and LVN

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