Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype

Masakazu Hayashida, Makoto Nagashima, Yasuo Satoh, Ryoji Katoh, Megumi Tagami, Soichiro Ide, Shinya Kasai, Daisuke Nishizawa, Yasukazu Ogai, Junko Hasegawa, Hiroshi Komatsu, Ichiro Sora, Kenichi Fukuda, Hisashi Koga, Kazuo Hanaoka, Kazutaka Ikeda

Research output: Contribution to journalArticlepeer-review

113 Citations (Scopus)

Abstract

Aims: The association between SNPs of the human OPRM1 gene encoding the -opioid receptor and postoperative analgesic requirements in surgical patients remains controversial. Here, we evaluate whether any of the five tag SNPs (A118G, IVS2+G691C, IVS3+G5953A, IVS3+A8449G and TAA+A2109G) representing the four linkage disequilibrium blocks of the OPRM1 gene influences postoperative analgesic requirements. Materials & methods: We studied 138 adult Japanese patients who underwent major open abdominal surgery under combined general and epidural anesthesia and received continuous postoperative epidural analgesia with opioids. Results: The 118G homozygous (GG) patients required 24-h postoperative analgesics more than 118A homozygous (AA) and heterozygous (AG) patients. Tag SNP haplotypes also were associated with 24-h postoperative analgesic requirements. Conclusions: These results suggest that OPRM1 gene tag SNP genotypes and haplotypes can primarily contribute to prediction of postoperative analgesic requirements in individual patients undergoing major open abdominal surgery.

Original languageEnglish
Pages (from-to)1605-1616
Number of pages12
JournalPharmacogenomics
Volume9
Issue number11
DOIs
Publication statusPublished - 2008 Nov 1
Externally publishedYes

Keywords

  • μ-opioid receptor
  • analgesic
  • association study
  • haplotype analysis
  • OPRM1 gene
  • pain
  • SNP

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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