An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor

Keiichi Yoshikawa, Hiroaki Nakagawa, Naoki Mori, Hidenori Watanabe, Kazushige Touhara

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetradecen-1-ol is excreted into male mouse urine under androgen control and enhances urine attractiveness to female mice. This report is to our knowledge the first to describe natural product-based deorphanization of an odorant receptor.

Original languageEnglish
Pages (from-to)160-162
Number of pages3
JournalNature Chemical Biology
Volume9
Issue number3
DOIs
Publication statusPublished - 2013 Mar
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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